| Fatty acids and skin disorders |
| One of the active ingredients contained in PsoriaLess® includes a range of peroxidized oils, which proved to be extremely effective in a number of pharmaceutical, cosmetic, dermatological and rheumatic applications. A large number of studies (tests which were not carried out on animals) of over 1200 cases have been conducted in order to establish a variation of applications of the product. A patented process of directed peroxidation obtains the derivative of the natural oil concerned. The final product is a mixture of oxygenated glycerides (constituted of tri-esterified glycerol by non-saturated fatty acids, poly-oxygenated (linoleic, palmitic acid). This active ingredient, contained in PsoriaLess®, contains an important proportion (up to 65%) of linoleic acid derivatives which are chemically very near the derivatives from arachidonic acid. The usefulness of fatty acids in the treatment of a variety of skin disorders such as atopic dermatitis, psoriasis and related psoriatic-arthritis has been reported extensively. The efficacy of the pre-oxidized oils and their synergistic effects with the other active ingredients contained in PsoriaLess®, has proven to be overwhelmingly effective in the treatment of psoriasis, atopic dermatitis etc. Essential fatty acids have been shown to have beneficial effects in the treatment of skin disorders. |
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| This is likely to be due to effects on prostaglandin metabolism. In a 1997 Italian study, researchers treated 30 eczema patients with GLA (274 mg twice a day), and 30 with placebo for 12 weeks. During this time, the patients assessed their own symptoms and a dermatologist also assessed them every four weeks. The patients who received GLA showed gradual improvements in itching, redness, vesicle formation, and oozing, which were statistically significant compared with the control group. Essential fatty acid supplements may be beneficial in psoriasis sufferers. Analysis of blood and fat tissue has shown that the amount of anti-inflammatory alpha linolenic acid decreases, while the level of arachidonic acid, which has inflammatory effects, increases. These changes may be more pronounced in patients with severe psoriasis than in those with a milder form of the disease. |
| The results of a 1993 study suggest that eating oily fish may help reduce the symptoms of psoriasis. Some small studies suggest that fish oil supplementation may be beneficial in psoriasis. In a 1998 study, researchers from several European centers treated 83 patients with either an omega-3 fatty acid-based lipid emulsion or a placebo. |
| There were significant improvements in symptoms, as assessed by both the patients and the researchers. Essential fatty acid supplements also help to reduce the toxicity of immune-suppressant and vitamin A-derivative drugs. |
| Essential fatty acid supplements may be beneficial in psoriasis sufferers. |
| Intraepidermal lipid metabolism of keratinocytes and the respective metabolic disorders play a distinctive role in aetiopathogenesis of inflammatory skin diseases and offer new approaches in treatment. In atopic dermatits xerosis, reddening and scaling can be correlated to changes in the relative composition of epidermal lipids, especially ceramides that lead to defective water retention and disturbed barrier function of the skin. Also an endogenous d -6-desaturase deficiency, resulting in deficient formation of g -linoleic acid and its follow-up products with possible effects on prostaglandin synthesis and regulation on immune response have been suggested. Several studies testing local or oral substitution of g -linoleic acid in patients suffering from atopic dermatitis revealed inconsistent data, so that supplementation with evening primrose oil represents a well-tolerated additional therapy without consequences on basic therapy regimen in atopic dermatitis. Many results indicate that arachidonic acid and its follow-up products play a role in aetiopathogenesis of psoriasis. Therapeutic approaches attempt to substitute arachidonic acid by eicosapentaenoic acid (contained in fish oil), a biologically less active counterpart. Clinical studies on fish oil supplementation in psoriatic patients revealed positive effects when used as additional therapy but failed to establish a convincing basic therapy regimen. |
| In clinical studies the re-fatting effect of the active ingredients, the certain range of peroxidized oils referred to above, has been demonstrated and at the same time a significant decrease of the itching of dry skin could be proven. The peroxidized oils contained in PsoriaLess® were added as components to directly substitute coal tar. These extremely effective, yet very safe, range of natural ingredients are produced through a patented process of directed peroxidation which obtains the derivative of the natural oil concerned. The final product is a mixture of oxygenated glycerides (constituted of tri-esterified glycerol by non-saturated fatty acids, poly-oxygenated (linoleic, palmitic acid). |
| This active ingredient, incorporated in PsoriaLess® contains an important proportion (up to 65%) of linoleic acid derivatives which are chemically very near the derivatives from arachidonic acid. Created is a substance with optimal efficacy regarding itch relieving and replenishment of the skin. The product is free from solvents, with outstanding qualities for skin care applications. The components in this active ingredient contained in PsoriaLess® mainly include unsaturated essential fatty acids and their esters. The high content of linoleic acid in this natural active ingredient enhances the natural structure and maintenance of the epidermal lipid barrier. The re-fatting effect to the skin has been demonstrated in clinical studies. At the same time a significant decrease in itching with dry and scaly skin could be proven. Due to this property this natural active ingredient outweighs by far the caring effect of current other (oil) components and the product is therefore ideal for incorporation into dry and scaly skin care applications. The high degree in efficacy of this active ingredient on the skin is due to the unique combination of physiologically valuable fatty acids, vitamins and phytosterols. |
| Essential fatty acids, such as linoleic acid, can not be synthesized by the human body, but are of vital importance for the organism and especially for the skin. Keratinocytes need essential fatty acids, called vitamin F, for the biosynthesis of the membrane lipids in the horny layer (Stratum corneum) of the skin. Linoleic acid is crucial for the formation and maintenance of the epidermal permeability barrier. Certain ceramides, which are acylated with linoleic acid, strengthen the linkages between the lipid bi-layers and the corneocytes. |
| An intact permeability barrier minimizes the trans-epidermal water loss and, thus, protects the skin from drying. |
| Sensitive and dry skin is accompanied by inflammatory processes, which can lead to itching. In addition, linoleic acid is the starting material for the biosynthesis of prostaglandins which, for instance, have important immunoregulatory functions and influence epidermal keratinization. |
| Two major symptoms are associated with essential fatty acid deficiency. These are epidermal hyper proliferation (scaly skin) and a high level of transepidermal water loss. Not only the essential fatty acids play an important regulator role in the skin. Fatty acids such as palmitic, myristic, stearic and oleic acids form lipid double layers with ceramides and cholesterol, which act as a permeability barrier, as well. |
| Fatty acids contained in this active ingredient are physiological constituents of the skin and optimally support the natural epidermal shield. Vitamins play an important role in the delicate equilibrium (homeostasis) of the skin. Locally applied vitamins can reverse the degenerative processes related to skin aging. Vitamins of the B group stimulate cell respiration and fatty acid metabolism. Vitamin E (Alpha-Tocopherol) protects membranes from oxidative and radical damage (lipid peroxidation) and exhibits an anti-inflammatory effect. As a membrane stabilizing antioxidant, it can inhibit the release of histamine and hydrolytic enzymes from mast cells and lysosomes. Additionally, Alpha-Tocopherol inhibits the synthesis of Prostaglandin E2, which is known to have anti-pruritic effects. |
| In summary, it can be concluded that the constituents of the natural active ingredients described exert a positive synergistic effect on skin metabolism. |
| Cosmetic effects of natural peroxidized oils: |
| The cosmetic qualities of this natural active ingredient contained in PsoriaLess® were investigated. In controlled studies the itch relieving, skin replenishing and skin soothing effects of this natural active ingredient have been demonstrated. The positive influence by this active ingredient to the epidermal permeability barrier was determined by measuring the decrease of the transepidermal water loss. |
| Itch relieving and skin replenishing effects of a bath using peroxidized oils: |
| 230 stationary patients with atopic dermatitis were treated daily with a full bath containing 10 ml subject peroxidized oils in 80 l of water. This was done over a period varying from one to four weeks in addition to the usual clinical treatments. Along with the general clinical effects, the skin replenishment effect as well as the effects on the level/ degree of itching, were evaluated. |
| Results: |
| The tolerance of the baths was in all cases good to excellent. Side effects were not observed. |
| Assessment: | Excellent | Good | Satisfactory | | Itch relieving effect | 16% | 51% | 33% | | Replenishing Effect | 20% | 66% | 14% | | General clinical effects | 33% | 50% | 17% |
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| Effect of peroxidized oils on the epidermal barrier |
| The effect of subject peroxidized oils on the epidermal permeability barrier was confirmed by measurements of the transepidermal water loss. The measurements with an evaporimeter make it possible to evaluate the exchange of water between the epidermis and its environment. When the permeability barrier is improved by a product (in comparison to the placebo), the transepidermal water loss (TEWL) decreases. Six female volunteers aged between 20 and 55 years with dry skin on their forearms were recruited for the experiment. The transepidermal water loss was measured in two symmetrical areas of the forearms. Subject peroxidized oils were applied as a 5% formulation in one area and the corresponding placebo in the other area. The TEWL was measured after 30, 60 and 180 minutes. |
| Results: |
A single application of subject peroxidized oils decreases the TEWL:
· 12% after 30 minutes
· 15% after 60 minutes
· 14% after 180 minutes |
| Peroxidized oils promotes restoration of the epidermal permeability barrier after one single application. |
| Itch relieving and skin soothing effects of a topical treatment with a peroxidized oils -emulsion. |
Emulsions containing 5% of subject peroxidized oils were compared to placebo formulations. 100 patients either with atopic dermatitis or sebostatic dry skin were treated twice daily with preparations containing active ingredients and placebo preparations in a two-side test. The efficacy of the preparations was investigated in a double blind study. The following parameters were evaluated:
· Decrease of erythemal intensity
· Reduced itching |
| Results: |
· In 80 patients, the skin area treated with subject peroxidized oils showed a faster recuperation from the existing dermatitic alterations and a better relief from itching.
· In 76 patients, the intensity of the erythema was reduced in comparison to the placebo-treated control site.
· 84 patients preferred the preparation with the active ingredient over the placebo preparation. 16 patients found no difference between the preparations. None of the test persons preferred the placebo. |
| The exact ratio, concentrations, of the various active ingredients contained in PsoriaLess® are extremely important providing the highest degree of synergy between the various components resulting into optimum performance of the product. |
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| Allantoin |
| This compound is keratolytic and dissolves horn. Its application on the skin gives it therefore a smooth feeling. Allantoin enhances the growth of new healthy skin tissues. Allantoin is also successfully applied in ointments for the prevention of hyperthrophic scars, chronic leg ulcer and burns. One additional and most important activity is that it enhances the absorption of substances through skin tissue. Allantoin is not toxic and is also applied in oral indications. References: Allantoin in the treatment of psoriasis
Young E.
Dermatologica, 1973, 147 (5);338-341 Allantoin: a non-sensitizing topical medicament. Therapeutic effect of the addition of 5 percent allantoin to Vaseline.
Fisher A.A.
Cutis, 1981, 27(3);230-31,234,329 Topical use of Aloe Vera derived allantoin gel in otolaryngology
Thompson J.E.
Ear Nose Throat, 1991, 70(1); 56 Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis.
Garniclk JJ, Singh B, Winkley G.
Oral Surg oral Med Oral Pathol Oral Radiol Endod 1998 Nov;86(5):550-6 Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents.
Willital G.H., Heine H.
Int. J Pharmacol. Res. 1994, 14 (5-6); 193-202 A trial of silver-zinc-allantoin in the treatment of leg ulcers.
Margraf H.W., Covey T.H.
Arch.Surg, 1977, 112 (6); 699-704 |
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| Salicylic acid |
| Salicylic acid is widely used in products for the control of psoriasis. The Division of Drug labeling and Non-Prescription Drug Compliance of the FDA requires that an O.T.C. (over the counter) drug product for the control of psoriasis contains a minimum of 1.8 % and a maximum of 3 % salicylic acid. In prescription drugs the percentage is often higher. Application in percentages < 10 % is safe. Salicylic acid >6 % in ointment has a filter effect and interferes with UVB therapy for psoriasis. Adverse reactions are reported of an ointment with 10 % salicylic acid and an ointment with 40 % salicylic acid. |
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| References: |
Mometasone furoate 0.1%-salicylic acid 5% ointment versus mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis: a multicenter study.
Koo J, Cuffie CA, Tanner DJ, Bressinck R, Cornell RC, DeVillez RL, Edwards L, Breneman DL, Piacquadio DJ, Guzzo CA, Monroe EW Int J Dermatol 1997 Apr;36(4):309-12
Coal tar therapy in palmoplantar psoriasis: old wine in an old bottle
Kumar B, Kumar R, Kaur I Schweiz Rundsch Med Prax 1995 May 30; 84(22):649-53; Psoriasis: diagnosis and therapy. Panizzon R Cutis 1992 Oct; 50(4):307-9 Salicylate intoxication after use of topical salicylic acid ointment by a patient with psoriasis. Pec J, Strmenova M, Palencarova E, Pullmann R, Funiakova S, Visnovsky P, Buchanec J, Lazarova Z Nederlands Tijdschrift voor de Geneeskunde 1997 Oct 25;141(43):2075-9
Acute perceptive hearing loss and metabolic acidosis as complications of the topical treatment of psoriasis with salicylic acid-containing ointment.
Jongevos SF, Prens EP, Wolterbeek JH, Habets JM Acta Derm Venereol 1991;71(1):37-40
Topical salicylic acid interferes with UVB therapy for psoriasis.
Kristensen B, Kristensen O Hautarzt 1989;40 Suppl 9:61-2
Water content of the skin following salicylic acid and urea treatment.
Racz I, Soos G, Jakab E |
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 Treatment:
Wet with or
Soak in Dead Sea Salt Water Bath or Solution for 20 minutes
(alternatively in bath with baking soda) follow with
PsoriaLess Ointment at night under occlusion. Day time:
After shower rub in with PsoriaLess and let it dry in for
about 10 minutes and or cover with plastic wrap/cling film. |
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All prices
are free delivered to your home. |
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| Q & A Skin Problems l Questions & Answers |
| Questions by PsoriaLess® users, by people that just discovered they have perhaps psoriasis and questions from those that truly suffer and perhaps already for many years. We try to answer all questions. If you need advice on your skin condition just write to: info@psorialess.com |
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| PsoriaLess® is made by psoriasis sufferers for psoriasis sufferers |
| © PsoriaLess® 1995 |
